Efficient production of fully active, SARS-CoV-2-priming ... - PMC
The human TMPRSS2 (Transmembrane Protease, Serine 2) is composed of three distinct extracellular domains: SRCR Domain (Residues 150–242) Serine Protease (SP) Domain (Residues 243–492) 112149
Research utilizing computational tools like molecular docking and MD simulations has even explored how natural compounds—such as certain alkaloids—might interact with these specific protein structures to inhibit the virus's ability to infect a host. By focusing on the structural integrity provided by regions like the 112–149 domain, developers can better design medicines that potentially block the pathways utilized by SARS-CoV-2. Efficient production of fully active, SARS-CoV-2-priming
