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: Instead of compressing FASTQ and BAM files as independent silos, Deep exploits the fact that the BAM file is essentially a reorganized version of the FASTQ data.

Because BAM files originate from FASTQ files, they contain nearly identical sequence information, creating a massive that traditional compression (like GZIP or BGZF) treats as separate, redundant data. The "Deep" Compression Method 15p.zip

: Decompression is handled automatically by standard Genozip commands like genounzip (to restore the full set) or genocat (to extract a specific file). Comparison: Deep vs. Standard ZIP : Instead of compressing FASTQ and BAM files

: It uses the BAM file's alignment data to "predict" the contents of the FASTQ files. Only the differences (residual information) between the two are stored. Comparison: Deep vs

Introduced in , the "Deep" method (triggered by the --deep command) is a novel approach to co-compression . How It Works