Atopy typically follows a predictable chronological progression:
: Upon re-exposure, allergens cross-link IgE on the surface of mast cells, causing degranulation and the release of inflammatory mediators like histamine and leukotrienes. 2. The Atopic March allergic rhinitis (hay fever)
The core of atopy is a Type I hypersensitivity reaction driven by a Type 2 immune response. allergic rhinitis (hay fever)
Atopy is a genetic predisposition toward developing exaggerated IgE-mediated immune responses to common environmental allergens. Clinically, it manifests as a triad of conditions—, allergic rhinitis (hay fever) , and allergic asthma —often appearing sequentially in a pattern known as the "atopic march". 1. Pathophysiology and Mechanism allergic rhinitis (hay fever)