: Binding to Type I (ALK3/ALK6) and Type II (BMPR2) receptors triggers the phosphorylation of R-Smads (Smad1/5/8) , which complex with Smad4 and move into the nucleus to regulate gene expression.
: It primarily signals through two routes: : Binding to Type I (ALK3/ALK6) and Type
: It typically suppresses "default" neural differentiation to promote skin formation; however, in the adult brain, it helps maintain neural stem cell pools. Metabolic & Clinical Significance in the adult brain