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The U.S. government initiated , using piloted Sentinels to "protect" and effectively house-arrest the remaining mutants at the Xavier Institute. Son of M (2006) Series Summary

The storyline, specifically the Son of M (2006) limited series, follows the catastrophic aftermath of the "House of M" event where the Scarlet Witch depowered approximately 91.4% of the world's mutants with the phrase "No more mutants". Decimation (M-Day) Overview

: Known as "M-Day," this reality-altering act reduced the mutant population from millions to fewer than 200, an group often referred to as "The 198".

Human supremacist groups like the began hunting the newly vulnerable former mutants.