While the wedding takes center stage, the hospital remains in chaos due to a tragic car crash involving college students on their way to graduation.
: To promote the 100th episode, ABC created a real wedding website for Meredith and Derek that fans could actually visit and RSVP to. [S5E22] What a Difference a Day Makes
: After Derek and Bailey discover that Izzie has an inoperable brain tumor, the group decides to celebrate her life and love immediately. While the wedding takes center stage, the hospital
: Jeffrey Dean Morgan makes a final appearance as Denny Duquette, appearing as a hallucination to Izzie that Derek and Bailey eventually realize is a symptom of her worsening condition. Behind the Scenes Facts : Jeffrey Dean Morgan makes a final appearance
: Rhimes described the episode as the moment Meredith evolved from a "dark and twisty" girl into an "extraordinary" woman capable of choosing happiness.