4 Zip: Sgk1

phosphorylates Serine 422 at the C-terminal hydrophobic motif.

: Research compounds like EMD638683 , GSK650394 , and SI113 are being studied for their potential to treat cancer, metabolic disorders, and fibrotic diseases. Serum and glucocorticoid-regulated kinase 1 - Frontiers SGK1 4 zip

: Excessive SGK1 activity is linked to chronic inflammatory conditions and tissue fibrosis in the heart, lungs, and kidneys. Clinical Relevance a central catalytic kinase domain

then phosphorylates Threonine 256 within the kinase domain. SGK1 undergoes a two-step phosphorylation process:

: The human SGK1 protein is a serine/threonine-protein kinase consisting of 431 amino acids with a molecular mass of approximately 49 kDa . It features an N-terminal PX-like (phox homology) domain, a central catalytic kinase domain, and a C-terminal hydrophobic motif.

: To become fully functional, SGK1 undergoes a two-step phosphorylation process: