The lyric "I didn't even know it until they called her to the stage" refers to a real incident where T-Pain was shocked to find a bartender he frequently visited was actually a dancer.
T-Pain is known for writing from personal experience, and "Up Down" is no different:
Fans long debated the line "booty bigger than a simoleon." While some thought it was a mispronunciation of "Samoan," it was actually a reference to the Seminole tribe (the "Seminole" or "Simoleon" nickname), nodding to his Florida roots and Florida State University’s mascot.
The story of is more than just a club anthem; it was T-Pain’s defiant "I'm back" moment during one of the toughest stretches of his career.