Tm,cc,jp • No Password

The protein utilizes several C2 domains (C2A-C2F) to bind Ca 2+raised to the 2 plus power and lipids, as shown in the protein structure below. 2. C2 Domains: Function & Interactions

Structure and function of otoferlin, a synaptic protein of ... - PMC

Sensing: The C2D domain is identified as critical, as disruptions in this area alter synaptic sound encoding. tm,cc,jp

The binding requires cooperation between multiple C2 domains to secure the vesicle to the target membrane.

ions are bound per domain, with specific significance for the . The protein utilizes several C2 domains (C2A-C2F) to

It tethers vesicles to the plasma membrane, facilitating sound encoding.

Upon binding, a "closed" conformation is adopted, where C-terminal domains (C2F, C2G) rearrange. 3. Key Findings in Synaptic Transmission Ca 2+raised to the 2 plus power - PMC Sensing: The C2D domain is identified

Based on the 2025 research regarding the protein , which is crucial for hearing and synaptic transmission,