The series was created by and Alex Tse , ensuring an intimate and authentic look at the group's origins. While the show takes creative liberties and incorporates fictionalized drama, it is heavily inspired by the group's actual experiences. Members like Method Man, Ghostface Killah, and GZA served as consulting or executive producers to maintain the "Wu" spirit.

: Played by Shameik Moore , he initially belongs to a rival crew in Park Hill.

: Portrayed by T.J. Atoms , capturing the erratic energy of the late artist.

The series features a star-studded cast portraying the real-life members before they adopted their iconic stage names:

: Played by real-life rapper Dave East , a character balancing street ties with musical potential.

: Played by Ashton Sanders , he is the visionary leader attempting to steer his peers toward music.